IRCCS San Camillo Hospital Foundation

IRCCS San Camillo is a Scientific Hospitalization and Care Institute where the neurorehabilitation problems of neuromuscular and neurodegenerative diseases (eg Parkinson's, ALS) are addressed. The Biology laboratory deals with the study of the molecular mechanisms underlying neuro-degeneration in patients and establishes neurorehabilitative outcome biomarkers. Among these, for example, patients suffering from amyotrophic lateral sclerosis or muscular dystrophy

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Role of IRCCS San Camillo Hospital Foundation in the project INGENE 2.0

The role in the project is that of consultants for neuromuscular diagnostics and study of neuromuscular outcomes both of a clinical and biological nature, suggesting possible molecular or imaging biomarkers.

Profile of staff engaged in the project

Corrado Angelini Corrado Angelini Corrado Angelini was born in Italy. He graduated in Medicine and Specialized in Neurology in Padua. He attended the Mayo Clinic for 3 years (1970-1973) where he was Research Assistant and Associate, studying type 2 glycogenosis and describing the carnitine deficiency syndrome in humans. He was an MDA fellow in the UCLA Department of Neurology, working on Friedreich's ataxia and the systemic carnitine defect and in 1984 at the University of Colorado. He was Associate Professor and Full Professor at the University of Padua, using biochemical and molecular approaches in patient diagnostics and conducting clinical trials. He coordinated the Master of Neuromuscular Diseases in Padua and at the IRCCS San Camillo (2011-2013). He is conducting translational research at the IRCCS San Camillo in collaboration with the Universities of Bologna, Milan and TIGEM Naples. He is a FAAN member of the AAN, the EAN and the ANA. He is the founder of WMS and is part of the UIAA MedCom. He has received grants from the Telethon and AFM. Research interests Corrado Angelini has studied various muscle diseases contributing to the description of β-sarcoglycanopathy, dysferlinopathy and investigates the role of transporter-3 in girdle dystrophy. His research activity is directed to the treatment of patients suffering from metabolic disorders, myasthenia, mitochondria and ALS. He is currently interested in brain imaging and biomarkers (miRNA) that could help in the prognosis and rehabilitation of patients with motor disabilities.

Valentina Pegoraro Valentina Pegoraro Valentina Pegoraro is a Biotechnologist with experience in biomolecular techniques and translational research in the field of neuroscience. He received a degree in Biotechnology from the University of Padua in 2010 and a PhD in "Medical, Clinical and Experimental Sciences, Neuroscience" at the University of Padua in 2016, under the supervision of Prof. Angelini. She is currently a Post-Doc Researcher at IRCCS San Camillo where she works the study of biomarkers (e.g. specific MiRNAs) in serum, cell and muscle biopsies of rare and neuromuscular diseases that are correlated with the natural history, clinical scales and muscle MRI of patients to follow disease progression and the effect of rehabilitation. It also deals with the management of the BBMRNR Biobank of the IRCCS which is part of the European node BBMRI-ERIC and for which it is responsible for clinical risk.